|Tumor Microenvironment Laboratory|
|Paraic Kenny, Principal Investigator|
Giricz O, Calvo V, Peterson EA, Abouzeid CM and Kenny PA (2013) TACE-dependent TGF-alpha shedding drives triple-negative breast cancer cell invasion. International Journal of Cancer (in press) [PDF].
Calvo V and Kenny PA. (2013) Visualizing movement in the tumor microenvironment landscape. Breast Cancer Research 15:301. [PDF]
Curry MC, Peters AA, Kenny PA, Roberts-Thomson SJ and Monteith GR (2013) Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells. Biochem Biophys Res Comm434(3):695-700. [PDF]
Bhagat TD, Zhou L, Sokol L, Caceres G, Gundabolu K, Gordon S, Mantzaris I, Gligich O, Yu Y, Bhattacharyya S, Jing X, Polineni R, Tamari R, Bhatia K, Pellagatti A, Boultwood J, Kambhampati K, Steidl U, Stein C, Ju W, Liu G, Kenny PA, List A, Bitzer M and Verma A. (2013) miR-21 mediates hematopoietic suppression in MDS by activating TGF-b signaling. Blood 121(15):2875-81. [PDF].
Sparano JA, Ostrer H and Kenny PA (2013) Translating genomic research into clinical practice: Promises and pitfalls. ASCO Educational Book 15-23 [PDF].
Levano KS and Kenny PA (2012) Clarification of the C-terminal proteolytic processing site of human Amphiregulin. FEBS Letters 586(19):3500-2. [PDF].
Peterson EA, Shabbeer S and Kenny PA (2012) Normal range of serum Amphiregulin in healthy adult human females. Clin Biochem 43:460-463 [PDF].
Giricz O, Reynolds PA, Ramnauth A, Liu C, Wang T, Stead L, Childs G, Shapiro N, Fineberg S, Kenny PA and Loudig O. (2012) Hsa-miR-375 Is Differentially Expressed During Breast Lobular Neoplasia And Promotes Loss Of Mammary Acinar Polarity. Journal of Pathology 226:108-119 [PDF]. [Cited by 11]
Giricz O, Calvo V, Pero SC, Krag DN, Sparano JA and Kenny PA. (2012) GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Research and Treatment 133:607-615 [PDF] [Cited by 10].
Patsialou A, Wang Y, Lin J, Whitney K, Goswami S, Kenny PA and Condeelis JS. (2012). Selective gene expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Research 14(5):139 [PDF] [Cited by 2].
Peters AA, Simpson PT, Bassett JJ, Lee JM, Da Silva L, Reid LE, Song S, Parat MO, Lakhani SR, Kenny PA, Roberts-Thomson SJ and Monteith GR (2012) Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor negative breast cancer. Mol Cancer Therapeutics (10):2158-68. [PDF] [Cited by 2]
Curry MC, Luk NA, Kenny, PA, Roberts-Thomson SJ and Monteith GR. (2012) Distinct regulation of cytoplasmic calcium signals and cell death pathways by different plasma membrane calcium ATPase isoforms in MDA-MB-231 breast cancer cells. J Biol Chem 287(34):28598-28608 [PDF] [Cited by 6]
Falconer C, Kenny PA, Smart CE, Monteith GR, Roberts-Thomson S (2012) Peroxisome proliferator-activated receptor subtypes in mammary gland development and breast cancer. J Cancer Therapeutics & Research 1:14 [PDF].
Levano KS, Jung EH and Kenny PA (2011) Breast cancer subtypes express distinct receptor repertoires for tumor-associated macrophage derived cytokines. Biochem Biophys Res Comm 411 107-110 [PDF] [Cited by 3]
Sparano JA, Goldstein LJ, Childs BH, Shak S, Brassard D, Badve S, Baehner FL, Bugarini R, Rowley S, Perez EA, Shulman LN, Martino S, Davidson NE, Kenny PA, Sledge GW and Gray R . (2011) Relationship between quantitative GRB7 RNA expression and recurrence after adjuvant anthracycline chemotherapy in triple negative breast cancer. Clinical Cancer Research 17(22):7194-7203 [PDF] [Cited by 3].
Loudig O, Brandwein-Gensler M, Kim R, Lin J, Isayeva T, Segall JE, Kenny PA and Prystowsky MB (2011) Illumina Whole-Genome DASL Platform: Assessing Its Performance in Formalin-Fixed Paraffin-Embedded Samples and Its Applicability for Identification of Invasion-Related Genes in Aggressive Oral Squamous Cell Carcinoma. Human Pathology 42(12):1911-22 [PDF] [Cited by 11].
Davis FM, Kenny PA, Soo ETL, van Denderen BJW, Thomson EW, Cabot PJ, Parat MO, Roberts-Thomson SJ and Monteith GR. (2011) Remodeling of Purinergic Receptor-Mediated Ca2+ Signaling as a Consequence of EGF-Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells. PLOS One 6(8): e23464 [PDF] [Cited by 8].
McAndrew D, Grice DM, Peters AA, Davis FM, Stewart T, Rice M, Smart CE, Brown MA, Kenny PA, Roberts-Thomson SJ and Monteith GR (2011) ORAI1-mediated calcium influx in lactation and breast cancer. Mol Cancer Therapeutics 10(3):448-60 [PDF] [Cited by 15]
Feng M, Grice DM, Faddy HM, Nguyen N, Leitch S, Wang Y, Muend S, Kenny PA, Sukumar S, Roberts-Thomson S, Monteith G and Rao R (2010) Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors. Cell (143) 84-98 [PDF ][Cited by 48]
Grice DM, Vetter I, Faddy HM, Kenny PA, Roberts-Thomson SJ, and Monteith GR (2010). The golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231. J Biol Chem 285(48):37458-66 [PDF] [Cited by 13]
Han J, Chang H, Giricz O, Lee GY, Baehner FL, Gray JW, Bissell MJ, Kenny PA and Parvin B. Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture. Plos Computational Biology 6(2) e1000684 [PDF] [Cited by 18]
Chen A, Cuevas I, Kenny PA, Miyake H, Mace K, Ghajar C, Boudreau A, Bissell MJ and Boudreau N (2009). Endothelial cell migration and VEGF expression are the result of loss of breast tissue polarity. Cancer Research 69(16):6721-6729. [PDF] [Cited by 25]
Faddy HM, Smart CE, Xu R, Lee GY, Kenny PA, Feng M, Rao R, Brown MA, Bissell MJ, Roberts-Thomson SJ and Monteith GR (2008). Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochem Biophys Res Commun. 369(3):977-81 [PDF] [Cited by 25]
McBryan J, Howlin J, Kenny PA, Shioda T and Martin F (2007) ERα-CITED1 co-regulated genes expressed during pubertal mammary gland development: implications for breast cancer prognosis. Oncogene 26(44):6406-6419 [PDF] [Cited by 25]
Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW, Gray JW, Bissell MJ (2007) The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Molecular Oncology 1(1) 84-96 [PDF] [Cited by 205]
Fournier MV, Martin KJ, Kenny PA, Xhaja K, Bosch I, Yaswen P and Bissell MJ (2006). Gene expression signature in organized and growth arrested mammary acini predicts good outcome in brest cancer. Cancer Research 66 (14) 7095-7102 [PDF] [Cited by 74]
Bissell MJ, Kenny PA, Radisky DC (2005) Microenvironmental regulators of tissue structure and tumor progression – The role of matrix metalloproteinases in the loss of tissue polarity and induction of genomic instability. Cold Spring Harbor Symposia in Quantitative Biology Vol LXX 343-356 [PDF] [Cited by 118]
Bascom JL and Kenny PA (2005) Meeting Report - Keystone Symposium: The Role of Microenvironment in Tumor Induction and Progression, Banff, Canada, Feb 5th – Feb 10th 2005. Breast Cancer Research 7: 113-118 [PDF]
Citation counts courtesy of
Stages of Cancer Development, Chelsea House Publishers (2007) [Amazon]
Read the review of this book from the National Science Teachers Association.
Scientific News Coverage
Article on Paraic's receipt of Eastern Cooperative Oncology Group Translational Research Award in Oncology Times.
Our collaborative work on ORAI1/SPCA2 published in Cell (2010) has been highlighted in Nature Reviews Cancer.
Public Media Coverage
Kenny Lab featured in New York's Irish Echo newspaper
Differentation, November 2007. Special Issue on Receptor Signaling in Cancer
The Scientist, April 2006, Feature article on Tumor Ecology