Paraic Kenny, Principal Investigator
 
 
 
Publications

 

Research Articles

2014

Chandiramani N and Kenny PA (2014) Comparative analysis of GATA3 mutation profiles between Asian and Western breast cancer patients: Is there really a difference? Cancer (in press) [PDF]

So PL, Wang GY, Wang K, Chuang M, Chiueh  VC, Kenny PA and Epstein EH (2014) PI3K-Akt signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis. Cancer Prevention Research 7(4):407-17 [PDF].

2013

Peterson EA, Pectasides E, Shabbeer S, Wiechmann L, Sparano JA & Kenny PA. (2013) Evaluation of serum Amphiregulin levels in breast cancer patients and cancer-free controls. Experimental Hematology & Oncology 2(1):25 [PDF].

Miwa HE, Koba WR, Fine EJ, Giricz O, Kenny PA & Stanley P. (2013) Bisected, complex N-glycans and galectins in mouse mammary tumor progression and human breast cancer. Glycobiology 23(12):1477-1490 [PDF] [Cited by 1].

Zhou ZN, Sharma VP, Beaty, BP, Roh-Johnson M, Peterson EA, Van Rooijen N, Kenny PA, Wiley HS, Condeelis JS and Segall JE (2013) Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo. Oncogene (in press) [PDF] [Cited by 3].

Giricz O, Calvo V, Peterson EA, Abouzeid CM and Kenny PA (2013) TACE-dependent TGF-alpha shedding drives triple-negative breast cancer cell invasion. International Journal of Cancer 133:2587-2595 [PDF] [Cited by 2].

Calvo V and Kenny PA. (2013) Visualizing movement in the tumor microenvironment landscape. Breast Cancer Research 15:301. [PDF]

Curry MC, Peters AA, Kenny PA, Roberts-Thomson SJ and Monteith GR (2013) Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells. Biochem Biophys Res Comm434(3):695-700. [PDF] [Cited by 7]

Bhagat TD, Zhou L, Sokol L, Caceres G, Gundabolu K, Gordon S, Mantzaris I, Gligich O, Yu Y, Bhattacharyya S, Jing X, Polineni R, Tamari R, Bhatia K, Pellagatti A, Boultwood J, Kambhampati K, Steidl U, Stein C, Ju W, Liu G, Kenny PA, List A, Bitzer M and Verma A. (2013) miR-21 mediates hematopoietic suppression in MDS by activating TGF-b signaling. Blood 121(15):2875-81. [PDF] [Cited by 12].

Sparano JA, Ostrer H and Kenny PA (2013) Translating genomic research into clinical practice: Promises and pitfalls. ASCO Educational Book 15-23 [PDF].

2012

Levano KS and Kenny PA (2012) Clarification of the C-terminal proteolytic processing site of human Amphiregulin. FEBS Letters 586(19):3500-2. [PDF] [Cited by 2].

Peterson EA, Shabbeer S and Kenny PA (2012) Normal range of serum Amphiregulin in healthy adult human females. Clin Biochem 43:460-463 [PDF] [Cited by 2].

Giricz O, Reynolds PA, Ramnauth A, Liu C, Wang T, Stead L, Childs G, Shapiro N, Fineberg S, Kenny PA and Loudig O. (2012) Hsa-miR-375 Is Differentially Expressed During Breast Lobular Neoplasia And Promotes Loss Of Mammary Acinar Polarity. Journal of Pathology 226:108-119 [PDF]. [Cited by 26]

Giricz O, Calvo V, Pero SC, Krag DN, Sparano JA and Kenny PA. (2012) GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Research and Treatment 133:607-615 [PDF] [Cited by 16].

Patsialou A, Wang Y, Lin J, Whitney K, Goswami S, Kenny PA and Condeelis JS. (2012). Selective gene expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Research 14(5):139 [PDF] [Cited by 12].

Lee SY, Meier R, Furuta S, Lenburg ME, Kenny PA, Xu R and Bissell MJ (2012) FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. Journal Of Clinical Investigation [PDF] [Cited by 9]

Peters AA, Simpson PT, Bassett JJ, Lee JM, Da Silva L, Reid LE, Song S, Parat MO, Lakhani SR, Kenny PA, Roberts-Thomson SJ and Monteith GR (2012) Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor negative breast cancer. Mol Cancer Therapeutics (10):2158-68. [PDF] [Cited by 11]

Curry MC, Luk NA, Kenny, PA, Roberts-Thomson SJ and Monteith GR. (2012) Distinct regulation of cytoplasmic calcium signals and cell death pathways by different plasma membrane calcium ATPase isoforms in MDA-MB-231 breast cancer cells. J Biol Chem 287(34):28598-28608 [PDF] [Cited by 6]

Falconer C, Kenny PA, Smart CE, Monteith GR, Roberts-Thomson S (2012) Peroxisome proliferator-activated receptor subtypes in mammary gland development and breast cancer. J Cancer Therapeutics & Research 1:14 [PDF] [Cited by 1].

2011

Levano KS, Jung EH and Kenny PA (2011) Breast cancer subtypes express distinct receptor repertoires for tumor-associated macrophage derived cytokines. Biochem Biophys Res Comm 411 107-110 [PDF] [Cited by 9]

Sparano JA, Goldstein LJ, Childs BH, Shak S, Brassard D, Badve S, Baehner FL, Bugarini R, Rowley S, Perez EA, Shulman LN, Martino S, Davidson NE, Kenny PA, Sledge GW and Gray R . (2011) Relationship between quantitative GRB7 RNA expression and recurrence after adjuvant anthracycline chemotherapy in triple negative breast cancer. Clinical Cancer Research 17(22):7194-7203 [PDF] [Cited by 5].

Loudig O, Brandwein-Gensler M, Kim R, Lin J, Isayeva T, Segall JE, Kenny PA and Prystowsky MB (2011) Illumina Whole-Genome DASL Platform: Assessing Its Performance in Formalin-Fixed Paraffin-Embedded Samples and Its Applicability for Identification of Invasion-Related Genes in Aggressive Oral Squamous Cell Carcinoma. Human Pathology 42(12):1911-22 [PDF] [Cited by 16].

Davis FM, Kenny PA, Soo ETL, van Denderen BJW, Thomson EW, Cabot PJ, Parat MO, Roberts-Thomson SJ and Monteith GR. (2011) Remodeling of Purinergic Receptor-Mediated Ca2+ Signaling as a Consequence of EGF-Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells. PLOS One 6(8): e23464 [PDF] [Cited by 18].

McAndrew D, Grice DM, Peters AA, Davis FM, Stewart T, Rice M, Smart CE, Brown MA, Kenny PA, Roberts-Thomson SJ and Monteith GR (2011) ORAI1-mediated calcium influx in lactation and breast cancer. Mol Cancer Therapeutics 10(3):448-60 [PDF] [Cited by 31]

2010

Feng M, Grice DM, Faddy HM, Nguyen N, Leitch S, Wang Y, Muend S, Kenny PA, Sukumar S, Roberts-Thomson S, Monteith G and Rao R (2010) Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors. Cell (143) 84-98 [PDF ][Cited by 72]

Sparano JA, Fazzari M and Kenny PA (2010) Clinical application of gene expression profiling in breast cancer. Surgical Oncol Clinics North America (19):581-606. [PDF] [Cited by 9]

Grice DM, Vetter I, Faddy HM, Kenny PA, Roberts-Thomson SJ, and Monteith GR (2010). The golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231. J Biol Chem 285(48):37458-66 [PDF] [Cited by 18]

Han J, Chang H, Giricz O, Lee GY, Baehner FL, Gray JW, Bissell MJ, Kenny PA and Parvin B. Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture. Plos Computational Biology 6(2) e1000684 [PDF] [Cited by 36]

2009

Chen A, Cuevas I, Kenny PA, Miyake H, Mace K, Ghajar C, Boudreau A, Bissell MJ and Boudreau N (2009). Endothelial cell migration and VEGF expression are the result of loss of breast tissue polarity. Cancer Research 69(16):6721-6729. [PDF] [Cited by 28]

2008

Faddy HM, Smart CE, Xu R, Lee GY, Kenny PA, Feng M, Rao R, Brown MA, Bissell MJ, Roberts-Thomson SJ and Monteith GR (2008). Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochem Biophys Res Commun. 369(3):977-81 [PDF] [Cited by 35]

2007

Kenny PA and Bissell MJ (2007) Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest 117 (2) 337-345 [PDF] [Cited by 165]

Kenny PA (2007) Tackling EGFR signaling with TACE inhibitors: a rational target for metalloproteinase inhibitors in cancer. Expert Opinion on Therapeutic Targets 11(10):1287-1298 [PDF] [Cited by 23]

Kenny PA (2007) 3D extracellular matrix culture models of EGFR signaling and drug response. Biochemical Society Transactions 35(4):665-668 [PDF] [Cited by 16]

Kenny PA (2007) TACE: a new target in EGFR-dependent tumors. Differentiation 75(9) 800-808 [PDF] [Cited by 46]

McBryan J, Howlin J, Kenny PA, Shioda T and Martin F (2007) ERα-CITED1 co-regulated genes expressed during pubertal mammary gland development: implications for breast cancer prognosis. Oncogene 26(44):6406-6419 [PDF] [Cited by 29]

Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW, Gray JW, Bissell MJ (2007) The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Molecular Oncology 1(1) 84-96  [PDF] [Cited by 281]

Lee GY, Kenny PA, Lee EH and Bissell MJ (2007) 3D culture models of normal and malignant breast epithelial cells. Nature Methods 4(4):359-365 [PDF] [Cited by 413]

Kenny PA, Lee GY, and Bissell MJ (2007) Targeting the tumor microenvironment. Frontiers in Bioscience 12:3468-3474 [PDF] [Cited by 114]

Radisky DC, Kenny PA and Bissell MJ (2007) Fibrosis and cancer: Do myofibroblasts come from EMT? J Cell Biochem 101 (4):830-839. [PDF] [Cited by 184]

2006

Fournier MV, Martin KJ, Kenny PA, Xhaja K, Bosch I, Yaswen P and Bissell MJ (2006). Gene expression signature in organized and growth arrested mammary acini predicts good outcome in brest cancer. Cancer Research 66 (14) 7095-7102 [PDF] [Cited by 85]

Kenny PA, Nelson CM, Bissell, MJ (2006) The Ecology of Tumors. The Scientist 20 (4) 30-35 [PDF] [Cited by 9]

2005

Bissell MJ, Kenny PA, Radisky DC (2005) Microenvironmental regulators of tissue structure and tumor progression – The role of matrix metalloproteinases in the loss of tissue polarity and induction of genomic instability. Cold Spring Harbor Symposia in Quantitative Biology Vol LXX 343-356 [PDF] [Cited by 137]

Bascom JL and Kenny PA (2005) Meeting Report - Keystone Symposium: The Role of Microenvironment in Tumor Induction and Progression, Banff, Canada, Feb 5th – Feb 10th 2005. Breast Cancer Research 7: 113-118 [PDF]

Kenny PA, Enver T and Ashworth A (2005) Receptor and secreted targets of Wnt/beta-catenin signaling in mouse mammary epithelial cells. BMC Cancer 5 (1) 3 [PDF] [Cited by 43]

2003

Kenny PA and Bissell MJ (2003) Tumor reversion: Correction of malignant behavior by microenvironmental cues. International Journal of Cancer (107)  688-95 [PDF] [Cited by] [Cited by 228]

Kenny PA and Rizki A (2003) Meeting Report: 42nd Annual Meeting of the American Society for Cell Biology. Breast Cancer Research 5(3):147-53 [PDF] [Cited by 1]

2002

Kenny PA, Enver T and Ashworth A (2002) Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line. BMC Mol Biol. 3(1):13 [PDF] [Cited by 16]

1999

Kenny PA, Liston EM and Higgins DG (1999) Molecular evolution of immunoglobulin and fibronectin domains in Titin and related muscle proteins. Gene (232) 11-23 [PDF] [Cited by 50]

 

 

Citation counts courtesy of


 

 

 

Books

Stages of Cancer Development, Chelsea House Publishers (2007) [Amazon]

Read the review of this book from the National Science Teachers Association.

---

Scientific News Coverage

Article on Paraic's receipt of Eastern Cooperative Oncology Group Translational Research Award in Oncology Times.

---

Our collaborative work on ORAI1/SPCA2 published in Cell (2010) has been highlighted in Nature Reviews Cancer.

---

Our work on TACE in breast cancer (J Clin Invest 2007) has been highlighted by both Nature Reviews Cancer and Expert Review of Anticancer Therapy

---

Public Media Coverage

Kenny Lab featured in New York's Irish Echo newspaper

---

Kelly wins the Horst Schulz Prize in Biochemistry

---

Covers

Differentation, November 2007. Special Issue on Receptor Signaling in Cancer

The Scientist, April 2006, Feature article on Tumor Ecology